In this study, the challenges of the Sino-US rivalry under the presidencies of Donald Trump and Joe Biden are discussed. Trump trade and economic approach, and the product of tariffs and sanctions, with its America First wish attached on decreasing the general demand of the nation on Chinese production. The administration as a zero-sum game in which major emphasis was given to trade deficits, intellectual property theft, and not including vital areas of life in China. In this paper, potential economic and geopolitical consequences of these two opposite strategies, such as new patterns of international trade, the ability of China to cushion against economic shocks, the effect of these strategies on innovation, and technological leadership, are assessed. These presidencies are compared in the study and help to comprehend the shifting course of the U.S.-China economic relations and implications on the international balance of power.