The two countries being strategic partners, both Pakistan and China are confronted with a number of security threats and challenges in their respective regions. Internal security threats are a burning issue for Pakistan they include; terrorism, insurgency, sectarian violence, and separatist movements. These threats are often associated with various outside agents, especially countries, and neighbors in this case India and Afghanistan. Globally, China is now perceived as an emergent power and continues to be checked, especially, by powers such as America. In its own region, China too is not immune to security threats with the territorial disputes regarding the South China Sea or the border tensions with India. It is therefore expected that Pakistan like any ally to China will actively engage in coming up with ways and means of combating the above security threats and challenges. 

Pakistan and the United States have had a history of complex relations since the former's inception. After the 9/11 attacks, changes were observed in the foreign policy of the United States towards Pakistan, followed by a strategic shift in Pakistan’s approach towards its ally in Afghanistan. This study aims to analyze the implications of the post-9/11 Pak-U.S. alliance by examining the impacts of terrorism and U.S. drone strikes on Pakistan’s national security. The theoretical framework focuses on John Mearsheimer’s theory of offensive realism. The study employs qualitative research methodology and focuses on secondary data. This research argues that as a result of the post-9/11 Pak-U.S. alliance, the national security of Pakistan was compromised. This study opines that a pragmatic foreign policy combined with a comprehensive national security approach is of paramount importance to Pakistan in order to survive and progress.